Primary nephrotic syndrome
Conditions
Interventions
Other primary nephrotic syndrome groups:None
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age>=18 years old, gender is not limited; 2. Biopsy confirmed primary nephrotic syndrome, including membranous nephropathy (MN), minimal change nephropathy (MCD), mesangial proliferative glomerulonephritis (MsPGN), focal segmental glomerulosclerosis (FSGS), IgA nephropathy (IgAN), mesangial capillary glomerulonephritis (MPGN); 3. Patients with hormone resistance, drug resistance and frequent recurrence; 4. Have used at least one course of repertumab treatment; 5. At least 12 months of follow-up;
Exclusion criteria
Exclusion criteria: 1. Lupus nephritis, purpura nephritis, diabetic nephropathy and other secondary nephrotic syndromes; 2. Rituximab (RTX) or its biosimilars have been used within 3 months before enrollment or during treatment; 3. Participate in other drug clinical studies during treatment; 4. Combined with malignant tumors; 5. Received organ transplantation; 6. Lack of clinical data related to important research indicators (such as pathological type, recurrence, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma albumin;renal function;Antiphospholipase A2 antibody;blood fat;urinalysis;24-hour urinary protein quantification; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood B lymphocyte count;routine blood test;liver function;blood sugar; | — |
Countries
China
Contacts
Public ContactChang Wenxiu
Tianjin First Central Hospital
Outcome results
None listed