osteoarthritis
Conditions
Interventions
A:No intervention
B:tourniquet
C:tourniquet and low dose dexamethasone
D:tourniquet and high dose dexamethasone
Sponsors
West Chian Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients with primary or secondary osteoarthritis of the terminal knee joint on one side who are scheduled to undergo total knee arthroplasty in the Department of Orthopedics and Joint Surgery of our hospital for the first time; (2) aged 18 to 80; (3) patients who voluntarily participate in clinical trials and sign informed consent forms and have good compliance.
Exclusion criteria
Exclusion criteria: (1) Elevated inflammatory indicators before surgery: CRP >10mg/L, IL-6>15pg/L; (2) Preoperative hemoglobin level 15°, varus deformity>15°, valgus deformity>15°; (4) autoimmune and metabolic knee arthritis, such as rheumatoid arthritis and gouty arthritis; (5) people who have been taking hormones for a long time due to autoimmune diseases and kidney disease, and patients with hypercortisolism; (6) patients with diabetes whose blood sugar is difficult to control and patients with previous gastrointestinal bleeding and perforation; (7) patients who the investigator believes are not suitable to participate in this clinical trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale;Inflammation markers;Cumulative morphine use;blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital for Special Surgery knee score;Knee range of motion and circumference;myometry;Imaging to assess muscle volume;Intraoperative stress assessment for anaesthetists;Difficulty of anaesthesia and anaesthetic risk assessment; | — |
Countries
China
Contacts
Public ContactQiang Huang
West China Hospital,Sichuan University
Outcome results
None listed