Helicobacter pylori infection
Conditions
Interventions
Experimental group:Vonoprazan 20 mg bid and doxycycline 100 mg bid for 14 days
Control group:Vonoprazan 20 mg bid, amoxicillin 1000 mg tid for 14 days
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18-70 years old, male or female; (2) Patients with confirmed Hp infection: treatment-naïve patients with positive urea breath test (13C/14C); (3) Patients who have failed to be treated with traditional bismuth quadruple therapy in the past and have had no more than 2 treatments in the past. (4) The patient or his/her legal representative signs the informed consent form, understands and agrees to follow the requirements of the study.
Exclusion criteria
Exclusion criteria: (1) Patients who have used antacids, bismuth, antibiotics, probiotics and other drugs that may affect the test results in the past 4 weeks; (2) Patients with organic lesions such as digestive tract tumors and tumors in other parts, patients with bleeding tendency or bleeding in gastric ulcer in the past 4 weeks, and patients who have undergone gastric surgery; (3) Serious diseases that interfere with the test results: such as severe heart, lung, blood, endocrine diseases, liver and kidney insufficiency; (4) Patients who are allergic to the drugs used in this study; (5) Pregnant women, lactating women, and women who are trying to conceive recently; (6) Patients who have had previous gastric and esophageal surgery; (7) Participated in other drug studies within the previous three months; (8) Difficulty in completing follow-up or the presence of other factors affecting compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of incidence of adverse reactions;Comparison of compliance;Factors influencing eradication rate; | — |
Countries
China
Contacts
Public ContactDekui Zhang
Lanzhou University Second Hospita
Outcome results
None listed