Subacute herpes zoster
Conditions
Interventions
Apparent response after two nerve blocks (48-hour assessment, pain relief >=30%):None
No response after two nerve blocks (48-hour assessment, pain relief <=30%):None
Sponsors
The First Affiliated Hospital of the Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Meet the diagnostic criteria for herpes zoster with a VAS score of at least 60/100; (2) The herpes lesion area is located in the innervated area of the thoracic segment (T1-T12), and all of them are unilaterally affected; (3) Age>=18 years old; (4) the course of the disease lasts 5-10 weeks; (5) No history of drug abuse, alcohol, central system diseases, head injury and brain surgery; (6) Right-handed with normal intelligence, no history of consciousness disorder and mental illness; (7) Able to understand and complete clinical scales; (8) The patient agrees to participate in this study and signs the relevant informed consent.
Exclusion criteria
Exclusion criteria: (1)Personality or other mental disorders, behavioral disorders; (2) Pregnant or lactating patients; (3) Claustrophobia and magnetic resonance contraindications; (4) Patients who have received treatment for nerve damage; (5) Patients with severe heart, brain, liver, lung, kidney and other lesions and blood system abnormalities; (6) Patients with block site infection, coagulation dysfunction and related contraindications to nerve block.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in brain regions on fMRI in patients with subacute herpes zoster who may have developed a central sensitized PHN susceptibility (by discussing ALFF and FC); | — |
Secondary
| Measure | Time frame |
|---|---|
| McGill Pain Questionnaire (SF-MPQ);Beck Depression Rating Scale (BDI);Pittsburgh Sleep Quality Index (PSQI);Types and dosages of analgesics during treatment; | — |
Countries
China
Contacts
Public ContactGu Nan
The First Affiliated Hospital of the Air Force Military Medical University
Outcome results
None listed