gout with hyperuricemia
Conditions
Interventions
Gout+Febuxostat+probiotics,GFPR:febuxostat: 0.1 mg/tablet orally 2 times daily in the morning and evening for 3 months
Lactobacillus reuteri: 0.2g/bag, one sachet at a time, 2 times a day, morning and
Gout+Febuxostat+placebo,GFPL:febuxostat: 0.1 mg/tablet orally 2 times daily in the morning and evening for 3 months
Placebo: 0.2g/bag, one sachet at a time, 2 times a day, morning and evening, for 3 m
Sponsors
The Second People's Hospital of Jingdezhen
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Hyperuricemia and Gout (2019) described above. 2. Age>=18 years old, both male and female. 3. Blood uric acid concentration> 420µmol/L. 4. During the treatment period, you can actively cooperate with febuxostat + Lactobacillus reuteri according to the course of treatment. 5. Good spirit, normal cognition, informed consent of patients and their families and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who do not meet the inclusion criteria. 2. Those with serious organ diseases. 3. Those with immune system deficiencies. 4. Have taken uric acid-lowering drugs before inclusion. 5. Those who are allergic to the drugs used in this study. 6. Patients who resist related research work and have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota;Serum uric acid;Serum creatinine; | — |
Countries
China
Contacts
Public ContactHongying Yu
Jingdezhen Second People's Hospital
Outcome results
None listed