Schizophrenia
Conditions
Interventions
High precision tDCS stimulation group:High precision tDCS stimulation
Pseudo stimulus control group:Pseudo stimulus
Schizophrenic patients without aggressive behavior:None
Healthy control group:None
Sponsors
Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Schizophrenia patients with aggressive behavior: 1. meet the diagnostic criteria of DSM-5 schizophrenia; 2. Repeated (>= 3 times) physical aggression towards others, with the most recent occurrence within 1 year; 3. Stable medication for 3 months, with no change in medication plan in the past month; 4. Right handed, aged 18-50 years old; 5. Normal hearing, vision or corrected vision; 6. Can cooperate and willing to participate in this study, sign a written consent form. Schizophrenia patients without aggressive behavior: Except for those without aggressive behavior, the inclusion and exclusion criteria are the same as those for schizophrenia patients with aggressive behavior. Health control: 1. Those who do not meet the diagnosis in DSM-5 after SCID screening and have no family history of mental illness; 2. No aggressive behavior; 3. Right handed, aged 18-50 years old; 4. Normal hearing, vision or corrected vision; 5. Can cooperate and willing to participate in this study, sign a written consent form.
Exclusion criteria
Exclusion criteria: Schizophrenia patients with aggressive behavior: 1. have intellectual disabilities (based on Wechsler Intelligence Scale); 2. Serious physical illness, history of head trauma; 3. History of substance abuse such as drugs and alcohol; 4. There are contraindications for MRI; 5. History of electroconvulsive therapy within the past 6 months. Schizophrenia patients without aggressive behavior: Same as above. Health control: 1. Presence of intellectual disability (based on Wechsler Intelligence Scale); 2. Serious physical illness, history of head trauma; 3. History of substance abuse such as drugs and alcohol; 4. There are contraindications for MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting-state and task-state fMRI data;Resting-state and task-state fNIRS data;Behavioral indices of the competitive reaction time task and signal stop task; | — |
Secondary
| Measure | Time frame |
|---|---|
| PANSS;ITAQ;MOAS;BP-AQ;RPQ;BIS-11;STAXI-2; | — |
Countries
China
Contacts
Public ContactXiaoping Wang
Second Xiangya Hospital of Central South University
Outcome results
None listed