None
Conditions
Interventions
Oliceridine combined with propofol-etomidate group(OPE group):Oliceridine combined with propofol-etomidate sedation
Dezocine combined with propofol-etomidate group(DPE group):Dezocine combined with propofol-etomidate sedation
Sponsors
Weihai Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Elderly outpatients over 65 years of age; 2.ASA classification I to III; 3.Received painless gastroenteroscopy; 4. Patients gave informed consent and voluntarily participated in this study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with known allergy to therapeutic drugs, patients taking opioids or NSAIDs within 2 d prior to the examination with a history of recovery from anaesthesia for unusual surgery; 2. Those with a history of severe cardiac, cerebrovascular, respiratory, hepatic, renal and metabolic disorders, severe ischemic heart disease, and chronic pain; 3. Those with significant airway difficulties, nasopharyngeal or oesophageal cancer, and psychiatric disorders; 4. Those with a history of acute respiratory tract infections within 2 weeks that have not been history of acute respiratory infection within 2 weeks without cure; 5. those with neuromuscular system diseases, mental illness; 6. subjects who explicitly refused to participate in this study; 7. subjects who, in the opinion of the investigator, are not suitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The dosage of sedative drugs, including induction dosage, additional dosage, and total dosage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Flow Dynamics Indicators During Gastrointestinal Endoscopy;Indicators of Adverse Reactions During Gastrointestinal Endoscopy Examination;Indicators related to patient recovery after gastrointestinal endoscopy;Patients and related indicators of gastrointestinal endoscopy (general information of patients); | — |
Countries
China
Contacts
Public ContactNing Xu
Weihai Central Hospital
Outcome results
None listed