Analgesics-sedatives
Conditions
Interventions
Control group (Midazolam):midazolam group:loading dose0.01-0.05mg/kg, Maintenance dose 0.02-0.1mg/kg/h
Sponsors
Shandong University Qilu Hospital (Qingdao)
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: (1) Age >= 18 years old and < 80 years old; (2) meet the diagnostic criteria for mild to moderate ARDS; (3) mechanical ventilation for less than 48 hours prior to inclusion in the study; and (4) obtaining informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients requiring neuromuscular blocking agents or ECMO treatment; (2) Patients with severe heart disease, with LVEF < 50% or NYHA class III or higher; (3) Patients with severe hepatic or renal insufficiency (Child-Pugh class C or higher, CKD stage 4 or higher); (4) Patients with severe central nervous system diseases, such as traumatic brain injury, cerebral hemorrhage, cerebral infarction, or uncontrolled epilepsy; (5) Patients with neuromuscular diseases such as myasthenia gravis, Guillain-Barre syndrome, Parkinson's disease, Alzheimer's disease, etc.; (6) Patients with an estimated survival time of < 48 hours; (7) Patients with a history of drug abuse, addiction, alcoholism, or long-term use of psychotropic drugs within the past 2 years prior to screening, or patients with chronic pain requiring long-term opioid therapy; (8) Any condition that prevents accurate assessment of cognitive function, such as language and sensory impairments or mental disorders (difficulty speaking or severe organic mental dysfunction); (9) Patients with severe arrhythmias, such as second-degree or third-degree atrioventricular block, severe bradycardia, etc.; (10) Pregnant or lactating women; (11) Patients for whom informed consent or authorization cannot be obtained; (12) Patients allergic toFospropofol disodium or other trial-related drugs; (13) Other situations deemed inappropriate for inclusion in the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 days of mechanical ventilation-free time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality;Incidence of delirium;Length of stay in ICU and Length Of Stay;Total amount of analgesic and sedative drugs used;Heart rate mean arterial pressure and respiratory rate ; | — |
Countries
China
Contacts
Public ContactGuo Xi
Shandong University Qilu Hospital (Qingdao)
Outcome results
None listed