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Effects of vaginal microorganisms on endometrium and embryonic development by inducing cell senescence

Effects of vaginal microorganisms on endometrium and embryonic development by inducing cell senescence

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500098749
Enrollment
Unknown
Registered
2025-03-13
Start date
2025-04-01
Completion date
Unknown
Last updated
2025-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Experimental group 1 (thin endometrium group):None
Experimental group 2 (pregnant women with abortion):None
Control group (normal endometrium group):None

Sponsors

Huazhong University of Science and Technology Union Shenzhen Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1.Age 18-40 years old (not menopausal); 2.In the past month, there were no following conditions: patients with no vaginal drugs, non-ovarian endometriosis cysts, patients with various vaginitis, patients with pelvic inflammatory disease and urinary tract infection; 3.No other underlying diseases; 4.Thin endometrium (B-ultrasound shows that the thickness of the endometrium in the midluteal stage is < 7mm); 5.Recent history of asexual life; 6.Patients with induced labor in the first and second trimesters of pregnancy; 7.Patients who sign informed consent.

Exclusion criteria

Exclusion criteria: 1.Poor patient compliance; 2.Massive active vaginal bleeding; 3.Reproductive tract tuberculosis without anti-tuberculosis treatment; 4.Severe heart, lung, liver, kidney and other organ diseases; 5.No history of sexual life.

Design outcomes

Primary

MeasureTime frame
Endometrial thickness;

Secondary

MeasureTime frame
Vaginal microbiota;Vaginal microecological function index;

Countries

China

Contacts

Public ContactLe Aiwen

Huazhong University of Science and Technology Union Shenzhen Hospital

leaiwen@126.com+86 180 3809 0785

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026