Overweight or Obesity.
Conditions
Interventions
Healthy control group:None
Overweight or Obesity Group:None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Healthy Subjects: 1. Subjects who voluntarily sign the informed consent form; 2. Age 18-70 years; 3.BMI=30.0 kg/m^2, (>=27 kg/m^2 and >=1 weight-related comorbidities (i.e., hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease)); 4. Eligible participants must have never used any weight loss drugs.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for Healthy Subjects: 1.HbA1c >= 48 mmol/mol (6.5%) 2. History of T1D or T2D 3. Treatment with hypoglycemic drugs 5 kg in 90 days prior to screening 9. Uncontrolled thyroid disease: TSH > 6.0 mIU/L or =100 ng/L at screening 11. Myocardial infarction, stroke, hospitalization for unstable angina, or TIA 60 days prior to screening 12. Patients with hepatic and renal insufficiency, systemic infection, malignant tumors or any other serious diseases or pregnant patients within 60 days prior to screening. Exclusion criteria for subjects who are overweight or obese 1. HbA1c >= 48 mmol/mol (6.5%) 2. History of T1D or T2D 3. Treatment with hypoglycemic drugs 5 kg 90 days prior to screening 9. Uncontrolled thyroid disease: TSH > 6.0 mIU/L or = 100 ng/L at screening 11. Myocardial infarction, stroke, hospitalization for unstable angina, or TIA 60 days prior to screening 12. Patients with hepatic and renal insufficiency, systemic infection, malignancy, or any other serious illness or pregnant patients within 60 days prior to screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood biochemistry;Body composition measurement data;Blood glucose;Insulin;Glycated hemoglobin;Novel circulating DNA levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete Blood Count (CBC); | — |
Countries
Chian
Contacts
Public ContactLixin Guo
Beijing Hospital
Outcome results
None listed