Alzheimers disease
Conditions
Interventions
Acute sleep deprivation group:24 hours of sleep deprivation
Non-acute sleep deprivation group:24 hours of a normal work-rest schedule
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 49 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-49 years old, male or female; 2. Subjects are Chinese (subjects born in China and currently settled in Chinese mainland, and their parents are of Chinese descent); 3. Healthy people (no clinically significant abnormal indicators or self-reported health in the physical examination report); 4. Sleep duration of 7–9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) less than 6 points, Epworth Sleepiness Scale (ESS) score less than 6 points); 5. Sign the informed consent form, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study.
Exclusion criteria
Exclusion criteria: Participants will be excluded if they meet any of the following conditions: a. Presence of day-night sleep reversal; b. Shift work within the past six months; c. Travel across time zones or experience of jet lag within the past three weeks; d. Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL [or 8 g] of pure alcohol); e. Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation; f. Family history of early-onset dementia; g. Self-Rating Depression Scale (SDS) score = 53, Self-Rating Anxiety Scale (SAS) score = 50, Mini-Mental State Examination (MMSE) < 28, Montreal Cognitive Assessment (MoCA) < 26; h.Female participants who are currently pregnant or breastfeeding; i. Individuals who need to drive or operate vehicles or machinery during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in peripheral blood Aß42 level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in peripheral blood t-tau level;Change in peripheral blood p-tau181 level;Change in peripheral blood p-tau217 level;Change in peripheral blood Aß40;Change in peripheral blood neurofilament light chain (NfL) level;Change in peripheral blood glial fibrillary acidic protein (GFAP) level;Proteomic profile changes;Changes in meridian values measured by Chinese Medicine meridian detection (electroconductivity method);Changes in assessment scores of the Chinese medicine Five-Organ Health Scale;Changes in evaluation scores of the Fatigue Scale (FS-14); | — |
Countries
China
Contacts
Public ContactLingling Liu
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed