ARDS
Conditions
Interventions
Severe pneumonia complicated with ARDS group:Extract peripheral blood and bronchoalveolar lavage fluid
Severe pneumonia without concurrent ARDS group:Extract peripheral blood and bronchoalveolar lavage fluid
Non severe pneumonia group:Extract peripheral blood and bronchoalveolar lavage fluid
Sponsors
Jing'an District Central Hospital, Shanghai
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Select elderly pneumonia patients admitted to the ICU of our hospital from October 2022 to September 2024; (2) Age >= 65 years old (according to WHO standards for developed countries); (3) According to the diagnostic criteria for severe pneumonia (CAP) by the Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS) in 2007; (4) According to the 2012 Berlin definition as the diagnostic criteria for ARDS; (5) I have not used any drugs that have an impact on the measurement indicators of this study in the past three months, such as antibiotics, hormones, immunosuppressants, etc; (6) Number of cases: 180 elderly patients with pneumonia;
Exclusion criteria
Exclusion criteria: (1) There is clear objective evidence of heart failure during the onset of respiratory failure; (2) Objective evidence of excessive fluid load during the onset of respiratory failure; (3) Exclude pulmonary edema caused by elevated hydrostatic pressure; (4) Patients with serious diseases such as chronic infections, immune system, cardiovascular system, central system, respiratory system, coagulation system, liver and kidney function, gastrointestinal dysfunction, etc. in the past 3 months; (5) Patients who died within one week of admission;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| microRNA-202-5p;MARCH6;angiopoietin-2;intercellular adhesion molecule-1;vascular endothelial growth factor;von willebrand factor; | — |
Countries
the People's Republic of China
Contacts
Public Contactxian JIN
Jing'an District Central Hospital, Shanghai
Outcome results
None listed