pMMR locally advanced rectal cancer
Conditions
Interventions
experimental group:Sequential CAPEOX regimen combined with trastuzumab after full course neoadjuvant long-term radiotherapy and chemotherapy
control group:Standard full course neoadjuvant long-term radiotherapy and chemotherapy
Sponsors
Gansu Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Ages between 18 and 70 years old; 2. Histopathologically confirmed rectal adenocarcinoma non-dMMR type; 3. Patients with a tumor lower edge distance from the anal verge 70 points; 6. No severe complications and obvious contrainations to radiotherapy, chemotherapy, and surgery; 7. No second primary tumor.
Exclusion criteria
Exclusion criteria: 1. Advanced rectal cancer confirmed by immunohistochemistry as dMMR/MSI-H; 2. Tumor lower margin 10 cm from the anal verge, low risk of recurrence (EMVI-, MRF-, lateral lymph nodes-, non-cT3-4); 3. Those with distant metastasis, severe comorbidities, and contraindications to radiotherapy, chemotherapy, and surgery; 4. Those with mental and diseases such as depression and mania; 5. Pregnant and lactating women; 6. Those who do not accept observation and are unwilling to be treated; 7.Those who are currently participating in other clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical complete response (CCR) rate;Pathological complete remission (PCR) rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative treatment for death cases;Perioperative mortality cases;Intestinal dysfunction;Anastomotic fistula;intestinal obstruction;Severe bone marrow suppression;Assessment of Quality of Life; | — |
Countries
China
Contacts
Public ContactZhou Xiadong
Gansu Provincial Cancer Hospita
Outcome results
None listed