Diseases that require total knee replacement surgery, such as knee osteoarthritis and knee joint injuries
Conditions
Interventions
Local injection group of simple bupivacaine liposomes:Local injection of bupivacaine liposomes alone to the patient (20ml bupivacaine liposomes+72mg bupivacaine hydrochloride+0.2mg adrenaline+40mg mor
Bupivacaine liposomal local injection group combined with postoperative intravenous PCA group:Administer local injection of bupivacaine liposomes into the patients knee joint (20ml bupivacaine liposom
Ropivacaine alone local injection group:Local injection of ropivacaine to the patient, cocktail formula (ropivacaine 200mg+0.2mg adrenaline+40mg morphine diluted to 70ml)
Local injection of ropivacaine combined with intravenous analgesia pump group:Local injection of ropivacaine was administered to the patient, with a cocktail formula (ropivacaine 200mg+0.2mg adrenalin
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 80 Years
Inclusion criteria
Inclusion criteria: 1: Having surgical indications 2: Initial total knee joint surface replacement treatment 3: Age<=80 years 4: Able to complete questionnaire surveys on their own or with the cooperation of family members 5: All patients and their families sign an informed consent form 6: BMI 18~30 kg/m^2 7: ASA Grade I-III
Exclusion criteria
Exclusion criteria: 1: Patients with infection at the puncture site 2: Patients with abnormal coagulation function 3: Individuals who are allergic to the drugs used in the study 4: ndividuals with mental illness who are unable to engage in language communication 5: Patients who are unwilling to sign informed consent forms 6: After completing the basic laboratory examination, the anesthesiologist team will evaluate those who have contraindications to surgical anesthesiaAfter completing the basic laboratory examination, the anesthesiologist team will evaluate those who have contraindications to surgical anesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue score (VAS) for pain;Rehabilitation Quality Assessment Score (Q15 Score);Analgesic pump usage;Walking distance;Knee joint range of motion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quadriceps muscle strength;Length of hospital stay;Hospitalization expenses;Dose of anesthesia drugs used during the surgical process;Perioperative vital signs;Patient's anesthesia duration during surgery;Sex;age;body mass index;Patient diagnosis and proposed surgical name;Usage of postoperative analgesic; | — |
Countries
China
Contacts
Public ContactLin chengxin
No. 6 Shuangyong Road, Qingxiu District, Nanning, Guangxi First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed