oral leukoplakia
Conditions
Interventions
Oral leukoplakia with diabetes mellitus group:None
Oral leukoplakia without diabetes mellitus group:None
Oral squamous cell carcinoma with diabetes mellitus group:None
Healthy control group with diabete:None
Healthy control group without diabete:None
Sponsors
Peking University School and Hospital of Stomatology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for the oral leukoplakia and oral squamous cell carcinoma group: 1 Patients with clinical and pathologic diagnosis of oral leukoplakia and oral squamous cell carcinoma; 2 18-75 years old, gender is not limited; 3 Informed and consenting to biopsy with complete information in the pathology report. 4 Patients with oral leukoplakia or oral squamous cell carcinoma with diabetes mellitus, with fasting blood glucose > 8.6 mmol/L or glycated hemoglobin > 7.0%. Patients without DM: no diagnosis of diabetes mellitus and fasting blood glucose 3.9 - 5.5 mmol/L or glycated hemoglobin 4.0%-6.0%; 5 Non-smoker or quit smoking for more than 10 years Healthy control group inclusion criteria: 1 Patients with clinical and pathologic diagnosis of mucous cysts and inflammatory hyperplasia; 2 18-75 years old, gender is not limited; 3 Complete information of pathology report. 4 Non-smoking or quit smoking for more than 10 years
Exclusion criteria
Exclusion criteria: Oral leukoplakia and oral squamous cell carcinoma group exclusion criteria: 1 History of radiation therapy to the head and neck; 2 Tumors other than oral cavity; 3 Pregnancy or lactation and minors; 4 Rapidly progressive systemic disease; 5 History of HIV infection or active hepatitis B or C disease; 6 Patients who are unable to cooperate for any reason. 7 History of betel nut chewing. Exclusion criteria for healthy controls: 1 History of head and neck radiation therapy; 2 Tumors other than those of the mouth and tongue; 3 Pregnancy or lactation and minors; 4 Rapidly progressive disease; 5 History of HIV infection or active hepatitis B or C disease; 6 Patients who are unable to cooperate for any reason; 7 History of betel nut chewing; 8 Presence of other oral mucosal disease in the mouth.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of different cell types;Differently expressed genes; | — |
Countries
China
Contacts
Public ContactHong Hua
Peking University School and Hospital of Stomatology
Outcome results
None listed