tourniquet hypertension
Conditions
Interventions
control group:none
modified femoral nerve block group:modified femoral nerve block performed 40 minutes preoperatively
Ischaemic preconditioning group:Ischaemic preconditioning operation 40 minutes before surgery
modified femoral nerve block block + ischaemic preconditioning (IPC) combined intervention group:modified femoral nerve block and ischemic preconditioning were performed 40 minutes before surgery.
Sponsors
The First People's Hospital of Qujing
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients who are going to undergo knee surgery under general anaesthesia in the operating theatre of the First People's Hospital of Qujing and need to use a tourniquet. Knee surgeries include total knee arthroplasty, arthrocleansing, cartilage repair, meniscectomy, meniscus repair, ligament reconstruction, osteotomy, and arthroplasty fusion. (2) Aged 18-75 years old; (3) BMI of 18-28 kg/m^2; (4) Voluntary signed informed consent;
Exclusion criteria
Exclusion criteria: (1) Patients with ASA >= grade IV; (2) Patients with contraindications to the drugs or any of the anaesthetic methods in this study (nerve block puncture site infection, allergy to anaesthetic drugs); (3) Tourniquet inflation time 150 minutes. (4) Patients with long-term anticoagulation; (5) Chronic pain and long-term use of opioid analgesic drugs; (6) Uncontrolled hypertension (systolic blood pressure >=160mmHg or diastolic blood pressure >=110mmHg in sitting position; systolic blood pressure 20mmHg. (8) Contraindications to tourniquet (peripheral vascular disease, peripheral neuropathy, previous arterial bypass graft and popliteal artery calcification); (9) Patients with previous knee surgery on the affected limb. (10)Patients with diabetes mellitus with poor glycaemic control (random blood glucose >=11.1 mmol/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative systolic pressure ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection of serum levels of inflammatory factors TNF-a, IL-6;Detection of serum levels of SOD, MDA;Detection of serum levels of iNOs, eNOs;Plasma D-dimer levels;FDP levels in plasma;Plasma levels of vWF;TM levels in plasma;VAS scores of patients; | — |
Countries
China
Contacts
Public ContactJiangang Li
The First People's Hospital of Qujing
Outcome results
None listed