Parkinson's disease
Conditions
Interventions
Observation group:take tenofovir disoproxil fumarate
control:use basic drugs
Sponsors
The Fourth Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients with Parkinson's disease with Hoehn Yahr grade 1~2.5; 2.Aged 18-65 years; 3.Cognitive function is normal (MMSE score >= 24 points), and can independently complete relevant scale surveys; 4.Patients volunteer to be tested and sign informed consent;
Exclusion criteria
Exclusion criteria: 1.Patients with Parkinsonism, essential tremor, stroke, epilepsy, and other well-diagnosed neurological disorders; or have undergone cranial surgery such as deep brain stimulation; 2.Patients with abnormal liver and kidney function (severe liver function abnormalities: ALT, conjugated bilirubin, AST, ALP, total bilirubin, one of which is greater than 2 times the upper limit of normal; Moderate to severe renal dysfunction: creatinine clearance <60ml/min); 3.Infected with chronic hepatitis B or AIDS (HIV-1 infection); 4.Severe depression, schizophrenia, other psychiatric disorders or drug dependence; 5.Other serious physical diseases such as heart, lung, liver, kidney disease, blood disease and malignant tumor; 6.Pregnant or lactating women and seniors over 65 years of age; 7.Allergy or other contraindications to the investigational drug; 8.Other conditions that, in the opinion of the investigator, are not suitable for participation in this clinical study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver and kidney function;UPDRS, Unified Parkinson's Disease Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum phospholipid;NMSS, Non-Motor Symptoms Scale; | — |
Countries
China
Contacts
Public ContactZhao Guohua
The Fourth Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed