None
Conditions
Interventions
Bicaine Liposome Opioid Frugality Strategy Group:Using 0.667% ultra long-acting bupivacaine liposomes for PIFPB to reduce opioid use
Control group:Induction, maintenance, and postoperative analgesia are performed according to the anesthesia routine of our cardiac surgery department
Ultra Low Dose Abamectin Frugality Strategy Group:Use of opioid drugs with an MSE of less than 25MSE in the bupivacaine liposome opioid frugality strategy group patients
Opioid Frugality Strategy Group:Use ropivacaine 0.35% for bilateral PIFPB, with a dosage of >=50MSE for opioid drugs
Low dose Atractylodes Frugality Strategy Group:Use of 25-50MSE opioid drugs in the bupivacaine liposome opioid frugality strategy group patients
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 18-80 years old; 2.Non emergency cardiac surgery; 3.ASA classification Class II-IV; 4.Body mass index (BMI) between 18 and 31; 5.Understand the experimental content before surgery and sign an informed consent form;
Exclusion criteria
Exclusion criteria: 1.The patient refuses or is unable to communicate clearly; 2.Accept non open chest minimally invasive surgery; 3.Severe liver and kidney dysfunction (alanine aminotransferase, aspartate aminotransferase, creatinine, and urea nitrogen test values exceeding the upper limit by 2 times); 4.Diabetes patients with poor blood glucose control (fasting blood glucose >= 12.0mmol/L); 5.Patients with sleep apnea syndrome; 6.History of chronic pain in the past; 7.Alcohol, sedative, and analgesic dependent or addicted patients; 8.Individuals who have used opioid drugs within 3 months prior to surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative cough and moderate to severe pain (VAS score >= 4) during hospitalization;The dosage of sufentanil used; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of times of remedial analgesia;Postoperative incidence of nausea and vomiting, dizziness;Postoperative systemic inflammation related indicators;Postoperative mechanical ventilation time;ICU stay time;Overall length of hospital stay;Overall hospitalization expenses;Incidence of stroke, myocardial infarction, renal insufficiency, and pulmonary complications;Chronic pain incidence rate; | — |
Countries
China
Contacts
Public ContactTao Tao
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed