Severe community-acquired pneumonia
Conditions
Interventions
Placebo group:Intravenous saline
Experimental group:Intravenous methylprednisolone sodium succinate
Sponsors
Second Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.>=18 years old; 2.Admitted to ICU; 3.Diagnosis of severe community-acquired pneumonia Community-acquired pneumonia can be diagnosed as severe pneumonia if one of the following primary criteria or >=3 secondary criteria are met: Main criteria: (1) Mechanical ventilation is required for tracheal intubation; (2) Septic shock still requires vasoactive drug therapy after active fluid resuscitation. Secondary criteria: (1) Respiratory rate > 30 times /min; (2) Oxygenation index 7.14mmol/L; (6) Systolic blood pressure < 90mmHg requires active fluid resuscitation; 4.Patients or clients sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Clinical history suggests aspiration of gastric contents; 2.The patient received invasive mechanical ventilation within 14 days before admission; 3.Patients who have been treated with antibiotics for respiratory infections for more than 5 days at admission (unless resistance to the antibiotic is isolated) Diseased body); 4.Patients with active tuberculosis or fungal infection, active viral hepatitis, or active herpes virus infection; 5.Patients who need glucocorticoids for any other reason; 6.Patients receiving more than 15mg/ day of prednisone (or equivalent) for more than 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day survival rate; | — |
Countries
China
Contacts
Public ContactLuo Hong
Second Xiangya Hospital, Central South University
Outcome results
None listed