gastrointestinal disease
Conditions
Interventions
RE Group:Remazolam 0.2mg/kg and esketamine 0.15mg/kg were used for induction of anesthesia
RR Group:Remazolam 0.2mg/kg and remifentanil 0.2µg/kg were used for induction of anesthesia
Sponsors
The First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1 Patients undergoing painless gastroenteroscopy in outpatient clinics; 2 aged 65 years and above; 3 American Society of Anesthesiologists (ASA) grades I - III.
Exclusion criteria
Exclusion criteria: 1 Patients with abnormal liver or kidney function; 2 known respiratory or endocrine diseases; 3 Patients with uncontrolled hypertension and NYHA classification ?-?; 4 Taking monoamine oxidase inhibitors, sedatives, analgesics, hypnotics, antipsychotics, antiemetics or antidepressants; 5 Addiction to tobacco and alcohol; 6 Patients allergic to the investigational drug; 7 expected difficult airway; 8 Body mass index (BMI) >35kg/m^2; 9 Have participated in other clinical trials within the past three months; 10 Patients with psychosocial illness or cognitive dysfunction and inability to cooperate or communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate;Incidence of hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression;Incidence of bradycardia;Induction time of anesthesia;Anesthesia recovery time;nausea ;Vomit;dizzy;hallucination;TIPS; | — |
Countries
China
Contacts
Public ContactLiu shujie
The First Affiliated Hospital of Harbin Medical University
Outcome results
None listed