Depression
Conditions
Interventions
SNT group:Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT)
rTMS:Conventional transcranial magnetic stimulation (TMS)
Healthy control group:None
Sponsors
Zhoushan second people's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 to 60 years; 2.Meets the diagnostic criteria for Major Depressive Disorder as specified in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 3.Total score of HAMD-17 > 17 points; 4.Right-handed; 5.Score of the Chinese version of the Beck Scale for Suicide Ideation (BSI-CV) >= 6 points; 6.The patient's physical examination, medical history, vital signs, routine blood, urine, and stool tests, liver and kidney function tests, electrolyte levels, electrocardiogram (ECG), electroencephalogram (EEG), and other indicators are normal; 7.After fully understanding the safety of transcranial magnetic stimulation (TMS), the patient is willing to actively cooperate with the treatment, and informed consent is signed by both the patient and their family members;
Exclusion criteria
Exclusion criteria: 1.Age 60 years; 2.Patients with a history of serious somatic diseases and depression caused by other psychoactive substances and non-dependent substances; 3.Patients with metal or electronic devices implanted in their bodies, such as intracranial metallic foreign bodies, cochlear implants, cardiac pacemakers, and stents; 4.Patients at risk of seizures, with a history of neurological disorders, head trauma, alcohol abuse, abnormal electroencephalogram (EEG), evidence of structural abnormalities in the brain on MRI, or a family history of epilepsy; 5.Patients with acute suicidal tendencies; 6.Patients with psychotic symptoms who require adjunctive antipsychotic medication; 7.Received ECT treatment within the 2 months prior to enrollment; 8.Pregnant, breastfeeding, or planning to become pregnant during the trial; 9.Patients who refuse to sign the informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety score;Suicidal ideation;Electrophysiological indicators; | — |
Countries
China
Contacts
Public ContactHuanping Zhan
Zhoushan second people's Hospital
Outcome results
None listed