Multidrug - resistant infections after liver transplantation
Conditions
Interventions
Exposure group:None
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged 18 years or above; 2.Patients who have undergone allogeneic liver transplantation and are receiving treatment with at least one immunosuppressive agent (Definition of immunosuppressive agents: glucocorticoids, calcineurin inhibitors, antimetabolites, mammalian target of rapamycin inhibitors, etc.). 3.Known or highly suspected to have multi - drug - resistant pathogen (MDR) infection. The MDR criteria conform to the definition in 'Chinese Expert Consensus on the Prevention and Control of Healthcare - associated Infections Caused by Multi - drug - resistant Organisms'. Multi - drug - resistant organisms (MDR) refer to bacteria that are simultaneously resistant to three or more categories of commonly used antimicrobial agents to which they are usually susceptible. 4.Having applied the initially selected or replacement anti - infectious treatment regimen for at least 3 days. 5.The clinical outcomes of the cases are complete, and the data can meet the evaluation of treatment outcomes (clinical outcomes, microbiological outcomes, and safety evaluation). 6.Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.There are obvious deficiencies in the selection or use of the treatment regimen in clinical evaluation. For example, when there are drugs sensitive in the drug sensitivity test, a single - drug regimen that is clearly shown to be resistant in the drug sensitivity test is selected. 2.The researchers believe that there are any interfering factors that may affect the test results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comprehensive efficacy;Clinical effective rate;Microbial clearance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical adverse events; | — |
Countries
China
Contacts
Public ContactZhengxin Wang
Huashan Hospital, Fudan University
Outcome results
None listed