Recurrent Implantation Failure
Conditions
Interventions
Hysteroscopy RIF group (Part One Research Group):no intervention
Hysteroscopy control group (Part One Control Group):no intervention
RIF study group (Part Two Research Group):Live Lactobacillus Capsule for Vaginal Use were administered to patients in the RIF study group
RIF control group (Part Two Control Group):According to standard medical procedures, there is no intervention
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. This study includes subjects aged 25-40 years who underwent hysteroscopy 4-7 days after ovulation or progesterone conversion. 2. Previous embryo transfer >=3 times, and a total of more than 3 high-quality subjects who have not yet obtained pregnancy are included in the RIF study group. The control group consisted of participants who had given birth and were currently undergoing routine hysteroscopy for endometrial polyps. 3. The chromosomes of both husband and wife of the experimental subjects are normal. 4. Agree to sign the informed consent form. RIF Study Group Inclusion Criteria: 1. This study included subjects aged 25-40 years old, with >=3 previous embryo transfers, and a total of more than 3 high-quality transfers that had not yet obtained pregnancy, to be included in the RIF cohort. 2. Both husband and wife have normal chromosomes. 3. Agree to sign the informed consent form.
Exclusion criteria
Exclusion criteria: Hysteroscopic RIF Group Exclusion Criteria: 1. Low ovarian reserve, FSH>12mIU/ml or AMH12mIU/ml or AMH<=1.1ng/ml; 2. Organic lesions such as uterine malformations, intrauterine adhesions, uterine submucosal fibroids, and large intramural fibroids; 3. Ultrasound shows that there is more hydrosalpinx untreated; 4. Subjects who have undergone vaginal washing, vaginal medication or oral antibiotic therapy in the past 1 week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vaginal microbiome;lactate;short-chain fatty acids; | — |
Countries
China
Contacts
Public ContactFu Min
Peking University Shenzhen Hospital
Outcome results
None listed