Acquired Immune Deficiency Syndrome
Conditions
Interventions
AIDS patients who discontinued NNRTI for more than 90 days:Same-day restart of B/F/TAF among HIV patients who experienced discontinuation from previous NNRTI-based regimens
Sponsors
National center for AlDS/STD control and prevention, China CDC
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with 18 years old or above. 2. Discontinuation of previous NNRTI based regimen for more than 90 days. 3. No known CrCl< 30mL/min or severe hepatic impairment. 4. No known or suspected resistance to BIC. 4. No known pregnancy
Exclusion criteria
Exclusion criteria: 1. Patients who are pregnant. 2. Patients who have abnormal liver and kidney function indicators(Child-pugh class C, CrCl< 30). Hepatitis virus co-infection does not serve as an exclusion criterion. 3. Patients who have historic resistance test indicating drug resistant to BIC or baseline resistance test indicating resistance to BIC. 4. Patients who are psychiatric illness or active tuberculosis co-infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HIV-RNA test results; | — |
Secondary
| Measure | Time frame |
|---|---|
| The reasons for discontinuation of B/F/TAF;HIV-RNA test results;Demographic characteristics;Parameters of quality of life and treatment satisfaction;Safety and tolerability on B/F/TAF;Drug resistance;The reasons of for discontinuation of prior therapy; | — |
Countries
China
Contacts
Public ContactZhao Yan
National center for AlDS/STD control and prevention, China CDC
Outcome results
None listed