Neurological critical illness
Conditions
Interventions
Control group:Sequential of Enteral nutrition suspension (SP) (7 days treatment) followed by Enteral nutritional emulsion (TP-HE).
Treatment group:Sequential therapy of Enteral nutrition emulsion (SP) (7 days treatment) followed by Enteral nutritional emulsion (TP-HE) (totally up.
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with severe stroke diagnosed by head trauma and CT or MRI, Glasgow score (GCS) =30g/L, total protein >=60g/L; 3. The patient is unable to eat normally due to coma or other reasons and needs nutritional therapy, and according to the clinical judgment of the investigator, the patient is suitable for tube feeding nutrition for at least 14 days; 4.NRS2002>=3, or m NUTRIC score > 5; 5. Age: >=18 Y; 6. Body mass index 18.5 kg/m^2>=(BMI)<35kg/m^2; 7. Hemodynamically stable; 8. Agree to join the study and have informed consent signed by the surrogate.
Exclusion criteria
Exclusion criteria: 1. The patient has contraindications to enteral nutrition, such as intestinal slowness, intestinal obstruction, gastric bleeding, gastric perforation, complete gastrointestinal failure, severe abdominal infection and intractable diarrhea; 2. The patient is receiving EN treatment; 3. The patient is receiving intravenous human albumin therapy; 4. Patients receive parenteral nutrition (including total parenteral nutrition and partial parenteral nutrition); 5. Patients with hypoproteinemia of primary diseases; 6. Severe hepatic insufficiency, Child-Pugh grade C or Wuhan meeting grading standard III; 7. Severe renal insufficiency, GRF< 30mL/min/1.73m^2; 8. Known allergy to test-related drugs; 9. Patient's inborn metabolism of the nutrients contained in the products in this study; 10. Pregnant or lactating women; 11. Enrollment in other studies; 12. Other conditions judged by the investigator to be unsuitable for participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of prealbumin from baseline at 14 days of enteral nutrition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Albumin levels after 7 and 14 days of enteral nutrition;Feeding amount and tolerance;Disease severity score;Severity of infection;Mortality; | — |
Countries
China
Contacts
Public ContactPan Jingye
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed