mild cognitive impairment
Conditions
Interventions
ALA-rich flaxseed oil group:Oral ALA-rich flaxseed oil capsules
corn oil group:Oral corn oil capsules
Sponsors
Chongqing Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Subjective perception of memory loss, with a disease duration of more than 3 months; 2. Objective examination with mild cognitive dysfunction, 18 points <= MoCA score <= 25 points (for those with less than 6 years of education, the total score will be evaluated after adding 1 point); 3. Depression scale for the elderly <= 10 points; 4. Basic activities of daily living are normal, but instrumental activities of daily living can be mildly impaired, and activities of daily living scale <= 18 points; 5. Dementia diagnostic criteria have not been met.
Exclusion criteria
Exclusion criteria: 1. Patients with neurological disorders that may cause cognitive dysfunction; 2. People with a history of depression, mania, anxiety, and other psychiatric disorders; 3. Patients with severe hepatic and renal dysfunction; 4. Those with a history of severe head trauma and a history of special medications; 5. Severe perceptual impairment and inability to complete cognitive function measurements. 6. Taking vitamin supplements, fish oil capsules, perilla seed oil, flaxseed oil capsules and other supplements in the last month, and refusing to stop taking nutritional supplements other than the intervention during the intervention period; 7. Consumption of walnuts exceeds 20g per day or 100g per week of fatty fish in the last month; 8. Cooking oil used is ALA-rich vegetable oil (e.g., flaxseed oil); 9. Continuous antibiotic use for more than three days within the past month; 10. Failure to consume the test samples as required, incomplete documentation affecting efficacy or safety evaluation, or non-compliance with project arrangements during the trial period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal flora and metabolites;Inflammation levels in the body; | — |
Countries
China
Contacts
Public ContactJiawei Yin
Department of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University, China
Outcome results
None listed