Refractory thin endometrium
Conditions
Interventions
Experimental Group:Medical Recombinant Collagen Treatment Solution
Sponsors
The Third Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.The age range is 20 to 40 years; 2.Body mass index (BMI) 18.5-24.9 kg/m^2; 3.Failed embryo transfer at our center during the previous cycle (within six months) with endometrial thickness data; 4.There is >= 1 transferable good quality frozen embryo; 5.Endometrial thickness <6mm after standardized treatment or after standard therapy; 6.Agree to the study protocol and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with uterine and endometrial lesions, including submucosal uterine fibroids, intramural uterine fibroids larger than 5cm or less than 5cm but affecting the morphology of the uterine cavity, endometrial polyps > 1cm, and intrauterine adhesions that affect pregnancy as assessed by the investigator; 2. Presence of hydrosalpinx visible on ultrasound that may affect pregnancy; 3. Previous surgery to confirm ASRM stage III~IV endometriosis; 4. Have recurrent miscarriage; 5. Uterine malformations, such as double uterus, unicornuate uterus, mediastinal uterus and other abnormalities; 6. Suffering from malignant tumors, such as breast cancer, ovarian cancer, cervical cancer, etc.; 7. Patients with major systemic diseases, endocrine or metabolic abnormalities (excluding controlled thyroid gland function diseases); 8. Patients with thromboembolic disease or previous history of thromboembolic disease; 9. Allergic constitution, including a known history of allergy to any ingredient in the investigational product (e.g., type III collagen).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endometrial thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Implantation rate;Clinical pregnancy rate;live birth rate;Fetal malformation rate;Pregnancy loss rate;Adverse event rate; | — |
Countries
China
Contacts
Public ContactLi Li
The Third Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed