Non-small cell lung cancer
Conditions
Interventions
RT:Prophylactic radiotherapy
Standard of Care:Standard treatment
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Pathologically confirmed NSCLC; 2. Presence of at least one asymptomatic or mildly symptomatic (no opioid required, NRS=2cm; 2) hip invasion (femoral head, femoral neck and acetabulum); 3) cortical invasion of the long bones (humerus, radius, ulna, clavicle, femur, tibia, fibula, metacarpals, and phalanges) 1/3 to 2/3; 4) invasion of the borderline vertebrae (C7-T1, T12-L1, and L5-S1) or posterior attachment of the vertebral body; 3. Performance status score of 0–2; 4. Age>=18 years; 5. Ability to provide informed consent; 6. Patients of childbearing potential must agree to use an effective method of contraception.
Exclusion criteria
Exclusion criteria: 1. Previous radiation therapy (RT) to the target treatment site; 2. Presence of serious medical comorbidities that preclude the treatment of radiation therapy (RT); 3. Pregnant or lactating females; 4. The target lesion is complex bone metastases, including clinical or radiographic evidence of spinal cord compression or impending pathological fracture of long bones (according to spinal unstable tumor score and Mirels criteria, respectively); 5. Combined with meningeal metastases; 6. Combined with malignant pleural effusion; 7. Absolute neutrophil count (ANC) < 1×10^9/L and platelet count (PLT) < 50×10^9/L at enrollment; 8. If enrollment in the trial would result in a clinical delay in the management of their treatment (e.g. the need for systemic or surgical treatment, and the enrollment trial would delay these treatments); 9. Have participated in clinical studies of other drugs or devices during the same period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of SREs; | — |
Countries
China
Contacts
Public ContactXiaojing Lai
Zhejiang Cancer Hospital
Outcome results
None listed