Schizophrenia
Conditions
Interventions
Research group:rTMS truly stimulating
Control group:rTMS pseudo stimulation
Sponsors
Suzhou Guangji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.The subject meets the ICD-10 diagnostic criteria for schizophrenia. 2.The subjects are aged between 18 and 45 years old and are right-handed. 3.The total PANSS score of the subject is = 25kg/m^2) after taking antipsychotic medication, and their weight remained stable (+/- 5%) for 4 weeks. 5.Abnormal EEG without clinical significance. 6.Participants and/or their guardians who sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1.Individuals with other severe mental disorders that meet the diagnostic criteria of ICD-10 Individuals with a history of severe head injuries or epileptic seizures Currently, there are other contraindications for the use of cochlear implants, pacemakers, in vivo metal implants, and fMRI or rTMS. 2.Individuals with a history of severe head injuries or epileptic seizures. 3.Currently, there are other contraindications for the use of cochlear implants, pacemakers, in vivo metal implants, and fMRI or rTMS. 4.Individuals who have used weight loss drugs or extremely low calorie diets within the past year, are pregnant or breastfeeding, have suffered from eating disorders or substance dependence Individuals with unstable cardiovascular disease (myocardial infarction or stroke within the past year, heart failure, acute limb ischemia, severe peripheral arterial occlusive disease). 5.Individuals with unstable cardiovascular disease (myocardial infarction or stroke within the past year, heart failure, acute limb ischemia, severe peripheral arterial occlusive disease). 6.Individuals with other potential causes of obesity (hypothyroidism, Cushing's syndrome, hypogonadism, insulinoma). 7.Individuals who have used non convulsive electroconvulsive therapy, tDCS, and other physical therapies within the past six months. 8.Subjects with a history indicating or determined by the researcher to have a significant tendency towards suicide and violence in the current or past 6 months, or those at risk of suicide and violence based on the researcher's clinical assessment, or those deemed unsuitable to participate in the trial by the researcher's assessment. 9.Pregnant, breastfeeding, or planning to conceive during the trial period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scales (VAS) score;Body mass index (BMI);Weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total calorie intake (TCI);Peripheral blood exosome levels;Resting state fMRI (rs-fMRI);Personal and social performance scale (PSP) score;Repeat able Battery for the Assessment of Neuropsychologhical Status (RBANS); | — |
Countries
China
Contacts
Public ContactZhang Guangya
Suzhou Guangji Hospital
Outcome results
None listed