Epilepsy
Conditions
Interventions
Test 1:Acute neuromodulatory stimulations (tACS, auditory stimulation, flicker light stimulation, short slow deep breathing).After patients were enrolled, the order of stimulation frequency was rand
Test 2:tDCS stimulation. After patients were enrolled, the order of true and sham stimuli was randomly assigned using a pre-generated random number table.
Test 3:Acupuncture stimulation (Baihui [GV20], Zusanli [ST36], Liangqiu [ST34], etc.). After the patients were enrolled, the order of stimulation of different acupoints was randomly assigned using a p
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age between 16 and 60 years. 2. Patients with drug-refractory epilepsy who require intracranial electrode implantation for clinical purposes, are in stable condition post-implantation, remain conscious, and have no severe surgical complications. 3. Normal intelligence and cognitive function (Montreal Cognitive Assessment [MOCA] score > 20), with the ability to cooperate in completing tasks and tests. 4. Normal unaided vision or corrected vision, with no color blindness, color weakness, or other visual impairments. 5. No history of mental illness, personality disorders, alcohol dependence, or drug abuse. 6. No major medical conditions other than epilepsy. 7. Willingness to participate in the study and provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1. Age below 16 or above 60 years. 2. Presence of severe chronic diseases other than epilepsy. 3. Severe cognitive impairment that hinders the ability to cooperate in tasks and tests. 4. Severe visual impairment that affects independent completion of the test. 5. Persistent high fever (>=39°C for >=5 days) or other serious complications following electrode implantation. 6. Refusal to participate in the study or to provide written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of neural oscillatory activity in brain regions and strength of functional connectivity between brain regions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcomes for each behavioral task, e.g., emotional picture scoring, inhibitory control, reward sensitivity, etc.;Pittsburgh sleep quality index, PSQI;Beck Anxiety Inventory, BAI;Beck Depression Inventory, BDI; | — |
Countries
China
Contacts
Public ContactQiangqiang Liu
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed