Early postoperative pain
Conditions
Interventions
Esketamine group:Esketamine
Sponsors
General Hospital of the Eastern Theatre of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA classification I-II or III 2. Age>=60 years old 3. Elective thoracoscopic lung resection (thoracoscopic lung wedge resection, lobectomy, segment resection)
Exclusion criteria
Exclusion criteria: 1. Allergy to S-ketamine 2. Unstable ischemic heart disease 3. Risk of increased intracranial pressure 4. Body mass index (BMI) > 35 kg/m² 5. Severe mental illness 6. Severe liver dysfunction (Child-Pugh grade C) 7. Renal failure (requiring renal replacement therapy) 8. Switch to thoracotomy surgery 9. Unable to read, write and understand Chinese 10. Unwilling to use PCIA or refuse to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with moderate to severe pain on the first postoperative day (Numerical Rating Scale [NRS] pain score =4 during coughing); | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS pain score at rest;NRS pain score during coughing;Asens Insomnia Scale Score;Hospital Anxiety and Depression Scale Score;Hemodynamic parameters;15-item Quality of Recovery score ; | — |
Countries
China
Contacts
Public ContactLidong Zhang
General Hospital of the Eastern Theatre of the Chinese People's Liberation Army
Outcome results
None listed