Acne
Conditions
Interventions
Control group:Benzoyl peroxide gel is used in the morning and adapalene gel in the evening
Experimental group:Azelaic Acid Combined with Glycolic Acid
Sponsors
Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. 18-40 years old, gender is not limited, a total of 48 people; 2. meet the diagnostic criteria for acne (facial acne, papules, pustules, nodules and cysts); 3. Patients with mild-to-moderate acne diagnosed according to the Chinese Acne Treatment Guidelines (2019 Edition) with the following facial features: (1) 20 - 50 inflammatory skin lesions (papules, pustules); (2) 30 - 100 non-inflammatory lesions (open and closed comedones); (3) No more than 2 facial nodules; GAGS score <= 30 points; 4. The patient voluntarily participates in this clinical study and signs a written informed consent form. and adhere to lifestyle considerations throughout the study: no use of other acne medications; Strenuous exercise should be avoided for 72 hours prior to the planned study visit.
Exclusion criteria
Exclusion criteria: 1. Facial suffering from other skin diseases, such as melasma, freckles and seborrheic dermatitis, which may affect the judgment of the test results; 2. Those who are allergic to the test product or have a high-allergy system; 3. Pregnant, pregnant, or lactating patients; 4. The results of laboratory tests of liver function and renal function are judged by doctors to be clinically significant abnormalities; 5. Patients with secondary acne, such as occupational acne and acne caused by sebaceous steroids; 6. Patients with oral antibiotics, glucocorticoids, spironolactone and other anti-androgens and other acne drugs within 4 weeks before the test; or patients who have used salicylic and chemical acids or physiotherapy for acne within 2 weeks; 7. Those who took oral retinoids within 2 months before the test (6 months of acitretinoin); 8. Facial plastic surgery, grinding, laser, injection therapy and other treatments in the 2 months before the test; 9. Patients with immunodeficiency diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of lesions;GAGS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| VISIA;Non-invasive skin physiological index detection; | — |
Countries
China
Contacts
Public ContactMa Hong
Affiliated Hospital of Jiangsu University
Outcome results
None listed