Mild active ulcerative colitis
Conditions
Interventions
Experimental group:Lactobacillus johnsonii+Mesalazine
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.>= 60 years old. 2. Clear diagnosis of mild active ulcerative colitis (i.e. diagnosis based on symptoms, laboratory tests, endoscopic findings; assessment of ulcerative colitis activity based on modified Mayo score). 3. Not adjusting the dosage of previous treatment drugs (including 5-aminosalicylic acid, immunosuppressants, biologics, etc.) within 2 weeks. 4. Not taking probiotics and related products within 2 weeks. 5. Voluntarily participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Used antibiotics within 2 weeks prior to treatment. 2. Current intestinal infection. 3. Use NSAIDs continuously for the first 5 days. 4. History of gastrointestinal surgery. 5. Serious systemic diseases, important organ diseases such as heart, lung, brain, liver and kidney dysfunction, malignant tumors, and other related diseases. 6. Individuals who are allergic to any component of probiotics observed. 7. Individuals who have participated in other intervention studies within the past 3 months prior to treatment or are unable to express their main complaints correctly or cooperate. 8. Pregnant or lactating women. 9. Vulnerable groups other than the elderly, including those with mental illness, cognitive impairment, critically ill patients, illiterate individuals, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sigmoidoscopy;Concentration of blood metabolites of Lactobacillus johnsonii; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood cell analysis and other blood indicators;Fecal analysis and other fecal indicators;Microbial abundance detection of fecal samples; | — |
Countries
China
Contacts
Public ContactShujie Chen
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed