Pain
Conditions
Interventions
Intervention group:Iposomal bupivacaine
Control group:Standard bupivacaine
Sponsors
Zhongshan Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 and 70 years; (2) ASA classification I–II; (3) Scheduled for elective abdominal surgery (including gastrointestinal surgery, biliary surgery, pancreatic surgery, etc.); (4) Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Allergic to any of the drugs used in the study; (2) ASA classification above II; (3) Contraindications to epidural anesthesia; (4) Patient refuses epidural anesthesia or is unable to cooperate; (5) Long-term use of analgesic medications in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative hydromorphone dose over 48 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS pain scores for resting and movement states at 24 hours, 48 hours, and 72 hours postoperatively.;Incidence of breakthrough pain at 24 hours, 48 hours, and 72 hours postoperatively.;Rescue opioid analgesic consumption.;Incidence of adverse reactions (hypotension, postoperative nausea and vomiting, itching, urinary retention, allergies, etc.;Time of first activation of the patient-controlled analgesia (PCA) pump;Hospital stay; | — |
Countries
China
Contacts
Public ContactLiang Chao
Zhongshan Hospital of Fudan University
Outcome results
None listed