Chronic Low Back Pain
Conditions
Interventions
Chronic low back pain gruop:None
Health control gruop:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1)CLBP group: a. Aged >=18 years; b. Numerical Pain Rating Scale (NPRS) score >=3; c. Persistent low back pain lasting more than 3 months; d. Signed informed consent. 2)Healthy control group (HC group): a. Aged >=18 years; b. No acute or recurrent low back pain in the past six months, no history of chronic pain; c. Demographic characteristics (age, gender, BMI) matched 1:1 with the CLBP group; d. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1)Low back pain caused by specific pathologies, such as diagnosed or known conditions like arthritis, tumors, neurological diseases, fractures, herniated discs, ankylosing spondylitis, or rheumatism. 2)Diagnosed with or having any condition that may cause motor impairment, such as vestibular disorders. 3)Having a mental illness, such as depression or schizophrenia. 4)Pregnant or with a history of chronic pain. 5)Any degree of injury to the skin around the lower back area. 6)Taking painkillers or psychiatric medications within 24 hours prior to the test. 7)Receiving treatments that affect the central nervous system, such as TMS or iTBS, within 48 hours before the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average change in oxygenated hemoglobin concentration in each brain region of interest compared to baseline.;The functional connectivity of each brain region of interest during the task;The electrical pain threshold on both sides of the L5 spinous process; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Oswestry Disability Index;Numeric Pain Rating Scale;Chinese Version of Fear-Avoidance Belief Questionnaire; | — |
Countries
China
Contacts
Public ContactLin Yang
West China Hospital, Sichuan University
Outcome results
None listed