A Study on the Threshold for Predicting Escalation of Anti-Reflux Therapy in Refractory GERD Patients Using 24-Hour pH-Impedance Monitoring (on-PPI)

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500098492

Enrollment

Unknown

Registered

2025-03-10

Start date

2025-03-10

Completion date

Unknown

Last updated

2025-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux disease

Interventions

rGERD group:None

control group:None

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age range: 18-75 years old; 2. Clearly diagnose refractory GERD; 3. Voluntarily participate in the research and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Other esophageal diseases besides rGERD; 2. History of upper gastrointestinal surgery; 3. Esophageal hiatal hernia >= 2cm; 4. Patients with severe heart and lung dysfunction or other diseases may not be able to tolerate relevant examinations or treatments; 5. Pregnant or lactating women;

Design outcomes

Primary

Measure	Time frame
Acid exposure time;pH combined with impedance monitoring parameter threshold;	—

Countries

China

Contacts

Public ContactHe suyu

Suining Central Hospital

hesuyu2009@163.com+86 180 0825 8565

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026