Hypertension
Conditions
Interventions
Renin Concentration Guidance Group:In the Renin Concentration Guided Group, measure standing renin concentration within 3 days before each follow-up visit. If blood pressure is not controlled, the fol
Traditional Empiric Therapy Group:Traditional Empiric Treatment Group will have their medication adjusted according to current domestic and international guidelines.
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients with primary hypertension; 2) Aged 18-75 years; 3) Either:No medication taken in the past week, with office blood pressure between 180/110 mmHg and 140/90 mmHg, and home self-measured blood pressure >=135/85 mmHg; or In the past month, use of a single antihypertensive medication with insufficient blood pressure control, with office blood pressure between 180/110 mmHg and 140/90 mmHg, and home self-measured blood pressure >=135/85 mmHg; 4) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1) White coat hypertension; 2) Secondary hypertension; 3) Pregnant women, breastfeeding women, or women planning to conceive; 4) Patients allergic to any of the following: diuretics, ACE inhibitors (ACEI), angiotensin receptor blockers (ARB), ß-blockers, or calcium channel blockers (CCB); 5) Patients who have had severe adverse reactions to diuretics, ACEI, ARB, or CCB in the past (excluding those with ACEI-induced cough); 6) Patients with contraindications to diuretics, ACEI, ARB, ß-blockers, or CCB; 7) Severe liver or kidney disease: creatinine >160 µmol/L, ALT and AST levels more than twice the normal upper limit, proteinuria >2+, hematuria; 8) Uncontrolled diabetes (fasting blood glucose >10 mmol/L); 9) History of congestive heart failure, cerebrovascular accident, or transient ischemic attack or hypertensive encephalopathy within the past year; 10) History of myocardial infarction or angina, or clinically significant arrhythmias recorded in the past 6 months; 11) Malignant hypertension; 12) Other diseases that may affect the study; 13) Poor compliance; 14) Individuals with cognitive impairment or those unable to perform daily self-care.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour ambulatory blood pressure;Reduction in office systolic blood pressure;Reduction in office diastolic blood pressure;24-hour ambulatory blood pressure monitoring: reduction in average systolic blood pressure for the entire day.;24-hour ambulatory blood pressure monitoring: reduction in average systolic blood pressure for the daytime.;24-hour ambulatory blood pressure monitoring: reduction in average systolic blood pressure for the nighttime.;24-hour ambulatory blood pressure monitoring: reduction in average diastolic blood pressure for the entire day.;24-hour ambulatory blood pressure monitoring: reduction in average diastolic blood pressure for the daytime.;24-hour ambulatory blood pressure monitoring: reduction in average diastolic blood pressure for the nighttime.;office systolic blood pressure ;office diastolic blood pressure; | — |
Countries
China
Contacts
Public ContactMa Wenjun
Fuwai Hospital
Outcome results
None listed