Postoperative quality of recovery
Conditions
Interventions
Sufentanil group:Anesthesia induction was induced by intravenous injection of sufentanil 0.1 µg/kg combined with propofol 1.5-3 mg/kg. According to the surgical operation and sedation score, propofol
Esketamine group:Anesthesia was induced by esketamine 0.2 mg/kg combined with propofol 1.5-3 mg/kg intravenously. According to the surgical operation and sedation score, propofol 0.5mg/kg was added in
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old 2. Outpatient gynecological surgery under anesthesia
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in this study 2. Contraindications to ketamine or esketamine, opioids, propofol 3. Alcohol addiction or drug dependence 4. Planning to become pregnant or needing to breastfeed 5. Previous history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis 6. Severe dementia or speech impairment that prevents them from communicating 7. Moderate or major depressive disorder treated with medication 8. Use ketamine or esketamine within a week 9. Those with a history of transient ischemic attack and stroke in the past 3 months 10. Those with a history of angina, myocardial infarction, heart failure, etc. in the past 3 months 11. Participation in other clinical trials 12. Severe renal impairment (requiring renal replacement therapy); Severe hepatic impairment (Child-Pugh class C)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative quality of recovery at 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of high-intensity injection pain;Length of the PACU stay;Sedation success rate;Postoperative quality of recovery at 48 hours;Anxiety and depression scale;Quality of sleep;Postoperative nausea and vomiting;Postoperative pain score;Postoperative fatigue score;Incidence of emergence agitation;Incidence of body movements;Incidence of dizziness or headache and hallucinations or nightmares;Clinician satisfaction;Patient satisfaction;Incidence of intraoperative awareness; | — |
Countries
China
Contacts
Public ContactWang Xulin
First Affiliated Hospital of Zhengzhou University
Outcome results
None listed