Alveolar bone defects
Conditions
Interventions
Experimental group:Implant BpNcCaP
Control group:Implant Bio-Oss
Sponsors
West China Hospital of stomatology, Si Chuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male or female between 18 and 70; 2. Need at least one tooth extraction and the present of one healthy adjacent tooth at the extraction site; 3. Signed informed consent form; 4. Have good oral hygiene habits.
Exclusion criteria
Exclusion criteria: 1. Liver and kidney function were obviously abnormal (AST, ALT, creatinine >= 1.5 times the upper limit of normal); 2. Coagulation disorders (APTT, PT, and FIB values are >= 1.5 times the upper limit of normal values); 3. Have a history of osteoporosis or are taking bisphosphonate therapy affecting bone regeneration; 4. History of radiotherapy and chemotherapy for maxillofacial,nasopharyngeal,or head and neck; 5. Severe degenerative disease; 6. Uncontrolled or obvious infection in local areas; 7. Sever systemic diseases; 8. Have systemic or local bone diseases such as bone tuberculosis, osteitis, bone tumors, etc; 9. Pregnant or breast feeding; 10. Plan to get pregnant within 12 months; 11. Long-term use of special drugs such as hormones, anticoagulants, etc 12. Mental abnormality, psychological disorders, neurological diseases (e.g.,epilepsy, etc.); 13. Uncontrolled endocrine and metabolic diseases, blood system diseases and cardiovascular diseases; 14. Smokers (>10 cigarettes) or poor oral hygiene; 15. Uncontrolled metabolic diseases such as diabetes, rickets, and thyroid disease; 16. Severe allergies; 17. Other conditions unsuitable for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in alveolar bone height; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in alveolar bone width;Implant area healing evaluation; | — |
Countries
China
Contacts
Public ContactXian Liu
West China Stomatology Hospital, Sichuan University
Outcome results
None listed