mycoplasma pneumoniae infection
Conditions
Interventions
Trial group:doxycycline
Sponsors
Children's Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
5 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Children in the outpatient and emergency department; 2. Age: 5-18 years old; 3. At the same time, the following clinical manifestations are met: (1) Fever (body temperature >=37.3°C); (2) cough; 4. Onset of disease <=5 days; 5. Meet the laboratory criteria for mycoplasma infection, that is, meet any of the following: (1) Positive mycoplasma nucleic acid test: including MP-DNA or MP-RNA detection; (2) Positive mycoplasma antigen test; 6. The guardian of the subject who has signed the informed consent form has a full understanding of the purpose of the trial, a basic understanding of the pharmacological characteristics of the experimental drug and possible adverse reactions, and voluntarily allows the child to participate in the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Doxycycline or azithromycin has been used; 2.Evidence of typical bacterial infection (clinical manifestations of coughing purulent sputum, laboratory test CRP >= 40mg/L); 3.Imaging findings: Chest X-ray or CT showing pulmonary consolidation of one or more lung lobes; 4.Respiratory failure requiring hospitalization; 5.Congenital bronchopulmonary dysplasia; 6.Serious basic diseases: including liver failure, kidney disease, heart failure, connective tissue disease, immunodeficiency disease, tumor, hypertension, diabetes, hemophagocytic syndrome, etc; 7.Contraindications for the use of azithromycin or doxycycline; 8.Children receiving other experimental drugs or instruments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospitalization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission rate and remission time of major symptoms (fever, cough, sputum, etc.); | — |
Countries
China
Contacts
Public ContactChen Zhengrong
Children's Hospital of Soochow University
Outcome results
None listed