Gingival redness, swelling, bleeding.
Conditions
Interventions
Experimental Group:Using Ke Li Ke Bee Venom Toothpaste.
Control Group:Using Ke Li Ke Toothpaste without Bee Venom.
Sponsors
Stomatological Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Good general health, no serious systemic diseases, at least 20 detectable natural teeth; 2. Aged between 18-70 years old, gender is not limited, if female, not in pregnancy and lactation and no pregnancy plan in the past six months; 3. At the screening visit, the plaque index score of the participants in the plaque inhibition trial was >=1.5, and the gingival index (BI) score of the participants in the gum problem reduction trial was >=1.0; 4. Willing not to clean the mouth in any form 8-16 hours before each study visit, not to consume any food or drink other than water in the morning on the day of each visit, and to stop drinking water 30 minutes before the start of the visit; 5. Willing to avoid the use of chemotherapy anti-plaque/antigingivitis products containing antimicrobial drugs during the study period, including but not limited to oral cleaning products containing fluamines, chlorhexidine, stannous fluoride, essential oils, cetylpyridine chloride, etc.; 6. Do not smoke or use other nicotine products; 7. Not participating in other similar pilot studies at the same time; 8. Sign the informed consent form and be able to complete the clinical trial as required.
Exclusion criteria
Exclusion criteria: 1. History of allergy to the test toothpaste ingredients; 2. Use of medications, such as antibiotics, that have an impact on the results of the trial within one month prior to enrollment in the study; 3. Open caries or mucosal lesions in the oral cavity; 4. Severe periodontitis (more than one tooth with a deep periodontal pocket of more than 5mm).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in the average plaque index at the 2nd week.;Change in the mean gingival index at week 12; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change in the average plaque index at the 1st week.;The change in the average gingival index at the 6th week.;Oral soft and hard tissue examination.; | — |
Countries
China
Contacts
Public ContactJianbo Li
Stomatological Hospital of Southern Medical University
Outcome results
None listed