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The specific brain function and network associated with chronic low back pain with depressive symptoms based on fNIRS

The specific brain function and network associated with chronic low back pain with depressive symptoms based on fNIRS

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500098396
Enrollment
Unknown
Registered
2025-03-07
Start date
2025-03-10
Completion date
Unknown
Last updated
2025-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic low back pain with depressive symptoms

Interventions

Chronic low back pain with depressive symptoms:None
Chronic low back pain:None
Health control:None

Sponsors

The Sixth Affiliated Hospital, Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.CNLBPD group: (1) Voluntarily sign the informed consent form; (2) Age 18-65 years; (3) Chronic low back pain symptoms lasting more than 3 months, complaining of pain symptoms for at least 3 days per week, pain symptom numeric rating scale (NRS) >= 3 points and 13 points. 2.CNLBP group: (1) Age 18-65 years; (2) Chronic low back pain symptoms lasting more than 3 months, complaining of pain symptoms for at least 3 days per week, and the Pain Symptom Numerical Rating Scale (NRS) >= 3 points and <=8 points; (3) BDI-II<=13 points. 3.Healthy control group: (1) Age 18-65 years; (2) No persistent low back pain symptoms in the past 3 months; (3) BDI-II<=13 points.

Exclusion criteria

Exclusion criteria: (1) Individuals diagnosed with depression who require antidepressant medication. (2) Individuals with specific or potential causes of low back pain (e.g., sciatica, spinal stenosis, lumbar disc herniation, spondylolisthesis, recent vertebral fractures, etc.). (3) Individuals with severe systemic or visceral diseases (e.g., inflammatory diseases, malignant tumors, unexplained weight loss, infections, or trauma). (4) Individuals with pain in other parts of the body that is more severe than low back pain. (5) Individuals with contraindications for fNIRS assessment. (6) Individuals with a BMI 30 kg/m^2. (7) Individuals unwilling or unable to complete the questionnaire survey or fNIRS measurements.

Design outcomes

Primary

MeasureTime frame
Changes in brain function;—

Secondary

MeasureTime frame
Depression;Oswestry Disability Index;Pain Catastrophizing Scale Score;Short Form 36 Health Survey Score;Numeric Rating Scale Score;—

Countries

China

Contacts

Public ContactYuling Wang

The Sixth Affiliated Hospital, Sun Yat-sen University

wangyul@mail.sysu.edu.cn+86 130 5444 5587

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026