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To explore the mechanism of acute intermittent hypoxia on the improvement of respiratory muscle motor control in patients with spinal cord injury based on neuroplasticity

To explore the mechanism of acute intermittent hypoxia on the improvement of respiratory muscle motor control in patients with spinal cord injury based on neuroplasticity

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500098393
Enrollment
Unknown
Registered
2025-03-07
Start date
2025-03-31
Completion date
Unknown
Last updated
2025-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal cord injury

Interventions

Acute intermittent hypoxia group:The patient sat and wore a mask for 15 times of intermittent acute hypoxia training, each time inhaling 10% oxygen for 1min, then ingestion 21% oxygen for 2min, altern
Placebo group:The patient sat and wore a mask to inhale 21% oxygen for 1 minute, followed by 21% oxygen for 2 minutes, 5 times a week for 4 weeks

Sponsors

Shanghai Yangzhi Rehabilitation Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Use of the American Spinal Cord Injury Association Injury Scale (AIS) to determine the neurological level and clinical motor integrity (severity) of spinal cord injury (1) Patients with spinal cord injury in the twelfth thoracic vertebra and above with injury degree A-B; (2) The duration of illness is less than 1 year; (3) Age 18-70 years old; (4) Can remain seated for half an hour with assistance; (5) Undiagnosed respiratory diseases such as chronic obstructive pneumonia, asthma, chronic bronchitis; (6) Voluntarily participate in the project and sign the informed consent.

Exclusion criteria

Exclusion criteria: (1) all kinds of acute, infectious, infectious diseases, visceral insufficiency; (2) suffering from other neurological diseases such as stroke and Parkinson's disease; (3) Severe cognitive impairment, Montreal cognitive assessment Moca<18; (4) Patients with pulmonary hypertension were diagnosed; (5) Those who do not cooperate with the test for other reasons.

Design outcomes

Primary

MeasureTime frame
Lung function;electromyogram of respiratory muscle;compound muscle action Potential;

Countries

China

Contacts

Public ContactLiu Benke

Shanghai Yangzhi Rehabilitation Hospital

1925711171@qq.com+86 199 5912 8063

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026