Depression in old age
Conditions
Interventions
intervention group:dTMS combined with SSRIs
Control group:Pseudostimulation combined with SSRIs treatment
Sponsors
Beijing Anding Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Patient signs written informed consent; 2) 60 years old = 17 5) Primary school education level or above, able to complete the scale assessment
Exclusion criteria
Exclusion criteria: 1) Those who are accompanied by suicidal ideation or suicidal behavior; 2) Those with a history of epilepsy or coronary heart disease or other serious unstable physical diseases; 3) Patients with a previous or current DSM-5 diagnosis of the following psychiatric disorders: organic mental disorder, Alzheimer's disease, secondary dementia due to other causes, schizophrenia, schizoaffective disorder, bipolar disorder, delusional disorder, undefined mental illness, patients with a history of substance abuse, including alcohol and active drug abuse in the past 12 months, except nicotine; 4) Participation in another interventional clinical study within the past 1 month; 5) Those who are unable to complete the experiment with severe aphasia, visual and hearing impairment, etc.; 6) Those who have undergone electroconvulsive therapy and transcranial magnetic stimulation therapy in the 3 months before screening 7) Use of non-SSRIs antidepressants in the past 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Between-group difference in change from baseline in the total score of the Participant Scale (HAMD-17) between the two groups at the end of 4 weeks;The power of the EEG a wave and the asymmetry of the a wave, taken as d (0. 5 ~ 4 Hz), ? (4 ~ 8 Hz), a (8 ~ 13 Hz), ß (13 ~ 30 Hz) energy values and ?/ß power ratios; | — |
Secondary
| Measure | Time frame |
|---|---|
| score of Pittsburghsleep Quality Index, PSQI;score of the Geriatric Depression Scale ,GDS; score of Hamilton Anxiety Rating Scale, HAMA; score of Montgomery-Asberg Depression Rating Scale, MADRS;score of Montreal Cognitive Assessment scale, MoCA;score of Activity of Daily Living Scale; | — |
Countries
China
Contacts
Public ContactQinge Zhang
Beijing Anding Hospital Affiliated to Capital Medical University
Outcome results
None listed