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Metabolomic study of hypertrophic cardiomyopathy

Characteristics of plasma metabolic profile changes and exploration of key pathways in patients with obstructive hypertrophic cardiomyopathy

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500098367
Enrollment
Unknown
Registered
2025-03-06
Start date
2023-08-08
Completion date
Unknown
Last updated
2025-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertrophic cardiomyopathy

Interventions

Obstructive hypertrophic cardiomyopathy group:None
Non-obstructive hypertrophic cardiomyopathy group:None
Normal control group:None

Sponsors

The First Hospital Affiliated of Air Force Medical University (Xijing Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Obstructive hypertrophic cardiomyopathy group: HCM patients with left ventricular outflow tract pressure difference >= 30 mmHg in both resting and stimulated states; voluntary acceptance of PIMSRA 2. Non-obstructive hypertrophic cardiomyopathy group: HCM patients with LV outflow tract pressure difference <30 mmHg in both resting and stimulated states. 3. Normal control group: normal population without comorbidities of other diseases.

Exclusion criteria

Exclusion criteria: 1. Obstructive hypertrophic cardiomyopathy group: patients with other diseases such as hypertension and diabetes mellitus in combination; patients who had undergone any surgery and related treatment; patients with incomplete information on key technical indicators; failure to collect blood specimens from patients at the appropriate time points; patients who were lost to visit. 2. Non-obstructive hypertrophic cardiomyopathy group: patients with other diseases such as hypertension, diabetes mellitus and etc.; patients who have received any surgery and related treatment; incomplete information on key technical indicators; patients whose blood specimens were not collected before surgery; failure to collect blood specimens from patients at the appropriate time points. 3. Normal control group: patients who have received any surgery and related treatment; incomplete information on key technical indicators; no blood specimens were collected from patients.

Design outcomes

Primary

MeasureTime frame
The pressure difference of the left ventricular outflow tract;

Secondary

MeasureTime frame
Structural indices of the heart at rest;Structural indices of the heart during exercise;Demographic information;Systolic function of the heart at rest;Diastolic function of the heart at rest;Systolic function of the heart during exercise;Diastolic function of the heart during exercise;

Countries

China

Contacts

Public ContactLiu Liwen

The First Hospital Affiliated of Air Force Medical University (Xijing Hospital)

liuliwen@fmmu.edu.cn+86 135 7197 5528

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026