Nausea and vomiting during pregnancy
Conditions
Interventions
Stellate ganglion block group:Under the guidance of ultrasound, the stellate ganglion block was performed with 0.8% lidocaine 5ml, once every other day, a total of 7 times.
Sponsors
Guangzhou Medical University Affiliated Women and Children's Center
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: B-ultrasound to confirm pregnancy; 18-45 years old; gestational age 7-14 weeks; Patients with NVP with a Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) score of >= 6; patient does not respond to conservative treatment including diet/lifestyle recommendations, according to the 2004 ACOG Practice Bulletin; The patient does not intend to terminate the pregnancy; Patient has signed written informed consent to participate in the study and agrees to follow the trial instructions and complete all required study visits.
Exclusion criteria
Exclusion criteria: 1. Being treated for NVP by other means; Patients who have been treated with SGB within 30 days for other reasons; 2. The investigator confirms that the patient's nausea and vomiting are causes other than NVP; Receiving treatment with other antiemetics; 3. Suffering from chronic diseases; 4. Infection at the puncture site; 5. Women who are unable to communicate in Chinese are excluded; 6. Atrioventricular block; 7. Patient has a history of allergy to any of the drugs involved in this clinical trial. 8. listlessness, pallor, dry skin, sunken eye sockets, and markedly reduced urine output (less than 400 ml of urine in 24 hours or less than 24 times for 5 times with low urine output). 9. Other digestive diseases that cause nausea and vomiting, such as gastrointestinal infection (accompanied by diarrhea), gastric ulcer (accompanied by epigastric pain or hematemesis), cholecystitis, biliary roundworm, pancreatitis (accompanied by abdominal pain, plasma amylase level rises to 5 ~ 10 times of the normal value), viral hepatitis (hepatitis virology positive, liver enzyme level >= 1 000 U/L) or acute fatty liver during pregnancy, gastrointestinal tumor. 10. Suffering from uncorrected endocrine system diseases, such as diabetes, hyperthyroidism, hypothyroidism, thyroid tumors, adrenal tumors, etc. 11. Suffering from neurological diseases, such as migraine, neuromyelitis optica, epilepsy, nervous system tumors, etc. 12. Blood biochemical indexes: serum potassium = 2 times the upper limit of normal; or renal insufficiency: elevated serum creatinine and urea nitrogen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PUQE score;HELP score;Urinary ketone bodies; | — |
Secondary
| Measure | Time frame |
|---|---|
| HCG;Pregnancy complication;Neonatal outcome;Number of persons requiring additional medication or treatment during treatment; | — |
Countries
China
Contacts
Public ContactCHEN Jinghui
Guangzhou Medical University Affiliated Women and Children's Center
Outcome results
None listed