Crohn's disease
Conditions
Interventions
Gold Standard:Masson’s trichrome staining of surgical pathology specimens, combined with histological fibrosis scoring, will be used as the gold standard to accurately assess the presence and severity
Index test:A deep learning model based on Magnetic Resonance Enterography (MRE) will be used to characterize the severity of intestinal fibrosis. The MRE parameters included in the analysis comprise M
Sponsors
First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Patients Over 18 years old with a confirmed diagnosis of CD based on the criteria of ECCO guideline. (2) Planning to receive a bowel resection due to stricture in ileum or colon, and availability of histological specimens of resected intestinal walls matched with MRE are expected to be available. (3) Clear boundaries of the target bowel tract enable accurate semi-automatic or fully automatic intestinal segmentation (4) Sign the informed consent form before enrolment.
Exclusion criteria
Exclusion criteria: (1) Cannot undergo MRI examination (2) Difficult to obtain suitable tissue after surgery (3) MRE imaging is of poor quality or contains artifacts (4) The target bowel is located at the anastomosis (ie, anastomotic stricture) (5) Intestinal lesions concurrent with other diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological score;Magnetic Resonance Enterography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Crohn's Disease Activity Index;IBD Montreal classification; | — |
Countries
China
Contacts
Public ContactMinhu Chen
The First Affiliated Hospital,Sun Yat-sen University
Outcome results
None listed