Hereditary Angioedema
Conditions
Interventions
treatment with Lanadelumab group:NA
Sponsors
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. According to the diagnostic criteria for HAE in Expert Consensus on the Diagnosis and Treatment of Hereditary Angioedema: (1) Clinical manifestations: recurrent skin and mucous membrane edema without response to antihistamines, glucocorticoids and epinephrine; (2) Family history: About 75% of patients had a family history of similar symptoms; (3) C1-INH and complement detection: In patients with HAE type 1, the concentration and function of serum complement C4 and C1-INH were low; In type 2 patients, the serum complement C4 and C1-INH function is low, but the concentration of C1-INH is normal or slightly increased. The level of serum C4, concentration and function of C1-INH were normal in patients with HAE-nC1-INH type. (4) For patients with HAE-nC1-INH, genetic testing is needed to make a clear diagnosis. 2. Able to understand the study method, willing to cooperate with the researchers, complete the follow-up prescribed by the study protocol, and voluntarily accept the disease-related questionnaire;
Exclusion criteria
Exclusion criteria: 1. Non-hae patients, including patients with allergic angioedema and acquired angioedema; 2. Those who are unwilling to participate in the follow-up required by the study protocol and voluntarily accept the disease-related questionnaire;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Attacks of angioedema; | — |
Secondary
| Measure | Time frame |
|---|---|
| Angioedema Control Test (AECT);Angioedema Quality of Life (AE-QoL) Questionnaire,;Hospital Anxiety and Depression Scale (HADS);post-treatment adverse reactions; | — |
Countries
China
Contacts
Public ContactXu Yanhua
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed