sufentanil-induced cough during induction of general anesthesia
Conditions
Interventions
Remifentanil group:Preinfusion with 0.1 ug/kg.min remifentanil for 5 minutes
Control group:Preinfusion with 0.1 ug/kg.min normal saline for 5 minutes
Sponsors
Air Force Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 100 ASA physical status I-II patients aged 18 to 65 years, weighing between 40 and 80 kg,and scheduled for elective surgery during general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Body weight exceeding 20% of the ideal body weight; 2. History of liver or kidney impairment; 3. Increased intracranial, intraabdominal or intraocular pressure before operation, depression, smoking, asthma, chronic cough, upper respiratory tract infection within one month of surgery; 4. Use of medications that could interfere with this study such as angiotensin-converting enzyme inhibitors, antidepressants, bronchodilators or steroidsa; 5. History of gastroesopha-geal reflux, hypertension, diabetes, heart disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of cough; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate; | — |
Countries
China
Contacts
Public ContactXueyue Zhou
Air Force Medical Center
Outcome results
None listed