knee osteoarthritis
Conditions
Interventions
Probiotic group:Lifestyle suggestion+glucosamine sulfate+probiotics (2 capsules, tid, 4 weeks)
Placebo group:Lifestyle suggestion+glucosamine sulfate+placebo (2 capsules, tid, 4 weeks)
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with unilateral or bilateral Osteoarthritis, KL grade 2-3 on knee weight-bearing radiographs; 2. Visual analogue scalescore greater than or equal to 3; 3. Age between 30-70; 4. Willing to comply with the research procedures and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous history of knee trauma and surgery, with extra-articular deformity; 2. Use of probiotics or antibiotics in the past 3 months; 3. Combined with rheumatoid, rheumatic, autoimmune, infectious, cardiovascular or respiratory chronic diseases; 4. Pregnant and lactating women; 5. Abnormal defecation or history of digestive tract diseases; 6. Patients known to be allergic to glucosamine sulfate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain improvement rate (proportion of patients with VAS score 2cm lower than baseline after 4 weeks of treatment); | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee joint functional indicators (WOMAC score, KOOS score);Systemic inflammation markers (LPS,LBP,TNF-a,IL-6,ESR);Gut microbiota testing;Adverse event rate; | — |
Countries
China
Contacts
Public ContactMing Cheng
The first affiliated hostipal of nanchang university
Outcome results
None listed